-354-IMMUNOLOGICAL STUDY IN IDIOPATHIC CARDIOMYOPATHY-LYMPHOCYTE SUBSETS AND NK CELL FUNCTION
نویسندگان
چکیده
منابع مشابه
T-lymphocyte subsets in idiopathic dilated cardiomyopathy.
Idiopathic dilated cardiomyopathy (IDC) is a common clinical problem in Africa. To determine if there is a defect of immune regulation in patients with IDC, the percentage of total T-cells (OKT3 positive), helper/inducer cells (OKT4 positive) and suppressor/cytotoxic cells (OKT8 positive) were measured using monoclonal antibodies in 20 patients with IDC and in 20 age-matched normal control subj...
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Suppressor T lymphocyte function was examined in 11 patients with idiopathic congestive cardiomyopathy and in 11 age and sex matched patients with a similar degree of heart failure resulting from ischaemic heart disease. Suppressor T lymphocyte function was also assessed in a control population of 11 normal subjects. Suppressor T lymphocyte function was reduced in both groups of patients with h...
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Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, ...
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Because abnormalities of the immune system may be involved in the pathogenesis of idiopathic congestive cardiomyopathy (ICCM), we studied suppressor cell function in patients with ICCM. Previously described in vitro techniques were modified for optimal demonstration of concanavalin A (con A)-inducible suppressor activity by peripheral blood mononuclear cells (PBM). Baseline responses in the mix...
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Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1986
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.50.565_2